Molecular Formula | C21H26N5NaO8S2 |
Molar Mass | 563.58 |
Solubility | DMSO: soluble1mg/mL |
Color | white |
Storage Condition | 2-8°C |
In vitro study | Mezlocillin sodium has in vitro antibacterial activity against Gram-positive, Gram-negative aerobic and anaerobic bacteria. mezlocillin has bactericidal activity by inhibiting cell wall synthesis, a process mediated by mezlocillin with penicillin-binding protein (PBPs). Mezlocillin is stable to hydrolysis by various β-lactamases, including penicillinase, cephalosporinase, and extended-spectrum β-lactamases. Mezlocillin binds to specific penicillin-binding proteins (PBPs) located within the bacterial cell wall, thereby inhibiting the third and final stages of bacterial cell wall synthesis. Cells are subsequently lysed under the action of bacterial cell wall autolytic enzymes, such as autolysin; This may be due to Mezlocillin interfering with autolysin inhibitors. Unlike many other penicillins, mezlocillin is extensively metabolized or excreted in the bile, with only about 50% of the dose appearing in normal urine. |
WGK Germany | 3 |
HS Code | 2941106000 |